The EADC‐ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: Evidence of validity

Author:

Frisoni Giovanni B.12,Jack Clifford R.3,Bocchetta Martina14,Bauer Corinna5,Frederiksen Kristian S.6,Liu Yawu7,Preboske Gregory3,Swihart Tim8,Blair Melanie9,Cavedo Enrica1,Grothe Michel J.10,Lanfredi Mariangela11,Martinez Oliver12,Nishikawa Masami13,Portegies Marileen14,Stoub Travis15,Ward Chadwich3,Apostolova Liana G.16,Ganzola Rossana17,Wolf Dominik18,Barkhof Frederik19,Bartzokis George20,DeCarli Charles12,Csernansky John G.21,deToledo‐Morrell Leyla15,Geerlings Mirjam I.14,Kaye Jeffrey8,Killiany Ronald J.5,Lehéricy Stephane22,Matsuda Hiroshi13,O'Brien John23,Silbert Lisa C.8,Scheltens Philip24,Soininen Hilkka7,Teipel Stefan1025,Waldemar Gunhild6,Fellgiebel Andreas18,Barnes Josephine9,Firbank Michael23,Gerritsen Lotte1426,Henneman Wouter19,Malykhin Nikolai27,Pruessner Jens C.28,Wang Lei29,Watson Craig12,Wolf Henrike3031,deLeon Mony32,Pantel Johannes33,Ferrari Clarissa11,Bosco Paolo1,Pasqualetti Patrizio3435,Duchesne Simon17,Duvernoy Henri36,Boccardi Marina1,Albert Marilyn S.12345,Bennet David12345,Camicioli Richard12345,Collins D. Louis12345,Dubois Bruno12345,Hampel Harald12345,denHeijer Tom12345,Hock Christofer12345,Jagust William12345,Launer Leonore12345,Maller Jerome J.12345,Mueller Susan12345,Sachdev Perminder12345,Simmons Andy12345,Thompson Paul M.12345,Visser Peter‐Jelle12345,Wahlund Lars‐Olof12345,Weiner Michael W.12345,Winblad Bengt12345,

Affiliation:

1. LENITEM (Laboratory of Epidemiology, Neuroimaging and Telemedicine) IRCCS – Istituto Centro S. Giovanni di Dio – FatebenefratelliBresciaItaly

2. Memory Clinic and LANVIE ‐ Laboratory of Neuroimaging of AgingUniversity Hospitals and University of GenevaGenevaSwitzerland

3. Department of Diagnostic RadiologyMayo Clinic and FoundationRochesterMNUSA

4. Department of Molecular and Translational MedicineUniversity of BresciaBresciaItaly

5. Department of Anatomy and NeurobiologyBoston University School of MedicineBostonMAUSA

6. Memory Disorders Research Group, Department of NeurologyRigshospitaletCopenhagenDenmark

7. Department of NeurologyUniversity of Eastern Finland and Kuopio University HospitalKuopioFinland

8. Department of NeurologyOregon Health & Science UniversityPortlandORUSA

9. Dementia Research Centre, Department of Neurodegenerative DiseaseUCL Institute of Neurology, National Hospital for Neurology and NeurosurgeryLondonUK

10. German Center for Neurodegenerative Diseases (DZNE)RostockGermany

11. Unit of PsychiatryIRCCS – Centro S. Giovanni di Dio – FatebenefratelliBresciaItaly

12. Department of NeurologyUniversity of CaliforniaDavisCAUSA

13. Kawamura Gakuen Woman's UniversityAbiko‐cityJapan

14. University Medical Center UtrechtJulius Center for Health Sciences and Primary CareUtrechtThe Netherlands

15. Department of Neurological SciencesRush UniversityChicagoILUSA

16. Mary S. Easton Center for Alzheimer's Disease Research and Laboratory of NeuroImaging, David Geffen School of Medicine, University of CaliforniaLos AngelesCAUSA

17. Department of RadiologyUniversité Laval and Centre de Recherche de l'Institut universitaire de santé mentale de QuébecQuebec CityCanada

18. Klinik für Psychiatrie und PsychotherapieJohannes Gutenberg‐Universität MainzMainzGermany

19. Department of Radiology and Nuclear MedicineImage Analysis Center, VU University Medical CenterAmsterdamThe Netherlands

20. Semel Institute for Neuroscience and Human BehaviorDavid Geffen School of Medicine at UCLALos AngelesCAUSA

21. Washington UniversityNorthwestern UniversityChicagoILUSA

22. Service de NeuroradiologieHopital de la Pitie‐SalpetriereParisFrance

23. Institute for Ageing and HealthNewcastle UniversityNewcastle upon TyneUK

24. Department of Neurology and Alzheimer CenterVU University Medical Cente and Neuroscience Campus AmsterdamAmsterdamThe Netherlands

25. Department of Psychosomatic MedicineUniversity of RostockRostockGermany

26. Department of Medical epidemiology and BiostatisticsKarolinska InstituteStockholmSweden

27. Department of Biomedical EngineeringCentre for Neuroscience, University of AlbertaEdmontonAlbertaCanada

28. Department of PsychiatryMcGill Centre for Studies in Aging, McGill UniversityMontrealQuebecCanada

29. Department of Psychiatry and Behavioral SciencesNorthwestern University Feinberg School of MedicineChicagoILUSA

30. Department of Psychiatry Research and Geriatric PsychiatryPsychiatric University HospitalsUniversity of ZurichZurichSwitzerland

31. German Center for Neurodegenerative Diseases (DZNE)BonnGermany

32. New York University School of MedicineCenter for Brain HealthNew YorkNYUSA

33. Institute of General PracticeGoethe‐University FrankfurtFrankfurtGermany

34. SeSMIT (Service for Medical Statistics and Information Technology), AFaR (Fatebenefratelli Association for Research), Fatebenefratelli HospitalRomeItaly

35. Unit of Clinical and Molecular EpidemiologyIRCCS “San Raffaele Pisana”RomeItaly

36. Chemin des RelançonsBesançonFrance

Funder

Alzheimer's Association

Brain Research Trust

National Institutes of Health

Alzheimer's Disease Neuroimaging Initiative

National Institute on Aging

National Institute of Biomedical Imaging and Bioengineering

Abbott Fund

Alzheimer's Drug Discovery Foundation

Amorfix Life Sciences

AstraZeneca

Bayer HealthCare

BioClinica

Biogen Idec

Bristol-Myers Squibb

Eisai

Eli Lilly and Company

Roche

GE Healthcare

Innogenetics

Medpace

Merck

Meso Scale Diagnostics

Novartis Pharmaceuticals Corporation

Pfizer

Servier

Synarc

Takeda Pharmaceutical Company

Canadian Institutes of Health Research

Lilly International

Wyeth International

Ministère du Développement Économique, de l'Innovation et de l'Exportation

Alzheimer's Research UK

NIHR Queen Square Dementia BRU

NIH

NIA ADC

Investissements d'avenir

Abbott

Amorfix Life Sciences Ltd.

BioClinica, Inc.

Biogen Idec Inc.

Bristol-Myers Squibb Company

Eisai Inc.

Elan Pharmaceuticals Inc.

F. Hoffmann-La Roche Ltd

Innogenetics, N.V.

IXICO Ltd.

Janssen Alzheimer Immunotherapy Research & Development, LLC.

Johnson & Johnson Pharmaceutical Research & Development LLC.

Medpace, Inc.

Merck & Co., Inc.

Meso Scale Diagnostics, LLC.

Pfizer Inc.

Synarc Inc.

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Clinical Neurology,Developmental Neuroscience,Health Policy,Epidemiology

Reference38 articles.

1. The clinical use of structural MRI in Alzheimer disease

2. Steps to standardization and validation of hippocampal volumetry as a biomarker in clinical trials and diagnostic criterion for Alzheimer's disease

3. Committee for Medicinal Products for Human Use (CHMP).Qualification opinion of low hippocampal volume (atrophy) by MRI for use in clinical trials for regulatory purpose ‐ in pre‐dementia stage of Alzheimer's disease. EMA/CHMP/SAWP/809208/2011. 17 November 2011.

4. Comparison of different MRI brain atrophy rate measures with clinical disease progression in AD

5. Tracking atrophy progression in familial Alzheimer's disease: a serial MRI study

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