Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype

Author:

Vermunt Lisa1,Sikkes Sietske A.M.12,Hout Ardo3,Handels Ron4,Bos Isabelle4,Flier Wiesje M.15,Kern Silke6,Ousset Pierre‐Jean7,Maruff Paul8,Skoog Ingmar6,Verhey Frans R.J.4,Freund‐Levi Yvonne91011,Tsolaki Magda12,Wallin Åsa K.13,Olde Rikkert Marcel14,Soininen Hilkka15,Spiru Luisa1617,Zetterberg Henrik18192021,Blennow Kaj1819,Scheltens Philip1,Muniz‐Terrera Graciela22,Visser Pieter Jelle14, , ,

Affiliation:

1. Department of NeurologyAlzheimer Center AmsterdamAmsterdam NeuroscienceAmsterdam UMCVrije Universiteit AmsterdamAmsterdamThe Netherlands

2. Department of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

3. Department of Statistical ScienceUniversity College LondonLondonUK

4. Department of Psychiatry and NeuropsychologySchool for Mental Health and Neuroscience (MHeNS)Alzheimer Centrum LimburgMaastricht UniversityMaastrichtThe Netherlands

5. Department of Epidemiology and BiostatisticsAmsterdam UMCVrije Universiteit AmsterdamAmsterdamThe Netherlands

6. Department of Psychiatry and NeurochemistryNeuropsychiatric Epidemiology UnitInstitute of Neuroscience and PhysiologySahlgrenska Academy at the University of GothenburgGothenburgSweden

7. CHU ToulouseGérontopôle and INSERM UMR 1027ToulouseFrance

8. Cogstate LtdFlorey InstituteUniversity of MelbourneMelbourneAustralia

9. Department of NeurobiologyCaring Sciences and Society (NVS)Karolinska University Hospital HuddingeStockholmSweden

10. Department of Old Age PsychiatryPsychology and NeuroscienceKing's College LondonLondonUK

11. School of Medical SciencesOrebro University Campus USÖÖrebroSweden

12. 3rd Department of NeurologyAristotle University of ThessalonikiMemory and Dementia Center“G Papanicolau” General HospitalThessalonikiGreece

13. Department of Clinical SciencesClinical Memory Research UnitLund UniversityMalmöSweden

14. Department of Geriatric MedicineRadboudumc Alzheimer CentreRadboud University Medical CenterNijmegenThe Netherlands

15. Institute of Clinical MedicineNeurologyUniversity of Eastern FinlandKuopioFinland

16. “Carol Davila” University of Medicine and PharmacyGeriatrics–Gerontology and Old Age Psychiatry Clinical Department –“Elias” University Clinical HospitalBucarestRomenia

17. “Ana Aslan” International Academy of Aging – The Memory Clinic and Longevity MedicineBucarestRomenia

18. Department of Psychiatry and NeurochemistryInstitute of Neuroscience and PhysiologyThe Sahlgrenska Academy at the University of GothenburgMölndalSweden

19. Clinical Neurochemistry LaboratorySahlgrenska University HospitalMölndalSweden

20. Department of Neurodegenerative DiseaseUCL Institute of NeurologyQueen SquareLondonUK

21. UK Dementia Research Institute at UCLLondonUK

22. Centre for Dementia PreventionUniversity of EdinburghEdinburghUK

Funder

Interreg

National Institutes of Health

Seventh Framework Programme

U.S. Department of Defense

Vetenskapsrådet

Forskningsrådet om Hälsa, Arbetsliv och Välfärd

Sahlgrenska Universitetssjukhuset

Alzheimer's Association

European Commission

European Brain Council

BIOMARKAPD

Actifcare

SNAC

Alzheimer Association Nederland

ZonMw

the Netherlands Organization of Scientific Research

Alzheimer Nederland

Cardiovascular Onderzoek Nederland

Stichting Dioraphte

Boehringer Ingelheim

Janssen Stellar

GE Healthcare

Merck

H2020 Induct

Pride Alzheimer UK

Innovative Medicine Initiative

Eli-Lilly

Janssen Pharmaceutical

Biogen

Integrative Analysis of Longitudinal Studies of Aging and Dementia

NIH

Stichting VUMC funds

ZonMW-Memorabel

Piramal Imaging

Stichting Alzheimer en Neuropsychiatrie

Alzheimer's Disease Neuroimaging Initiative

DOD

National Institute on Aging

National Institute of Biomedical Imaging and Bioengineering

AbbVie

Alzheimer's Drug Discovery Foundation

BioClinica, Inc.

Bristol-Myers Squibb Company

Eisai

Elan Pharmaceuticals, Inc.

Eli Lilly and Company

F. Hoffmann-La Roche Ltd.

Genentech, Inc.

Fujirebio

Janssen Alzheimer Immunotherapy Research & Development, LLC.

Johnson & Johnson Pharmaceutical Research & Development LLC.

Lundbeck

Merck & Co., Inc.

Meso Scale Diagnostics

NeuroRx Research

Novartis Pharmaceuticals Corporation

Pfizer Inc.

Servier

Takeda Pharmaceutical Company

Canadian Institutes of Health Research

Edith Cowan University

Mental Health Research Institute

Alzheimer's Australia

National Aging Research Institute

Austin Health, CogState Ltd.

Hollywood Private Hospital

Sir Charles Gardner Hospital

National Health and Medical Research Council

Science and Industry Endowment Fund

Australian Government Cooperative Research Center for Mental Health

Ana Aslan International foundation

Swedish Research Council

Swedish Research Council for Health, Working Life and Welfare

Sahlgrenska University Hospital

Janssen

University Hospital Center of Toulouse

Association Monegasque pour la recherche sur la maladie d'Alzheimer

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology

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