Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria

Author:

Dubois Bruno1,Hampel Harald12,Feldman Howard H.3,Scheltens Philip4,Aisen Paul5,Andrieu Sandrine6,Bakardjian Hovagim7,Benali Habib8,Bertram Lars910,Blennow Kaj11,Broich Karl12,Cavedo Enrica213,Crutch Sebastian14,Dartigues Jean‐François15,Duyckaerts Charles16,Epelbaum Stéphane1,Frisoni Giovanni B.1718,Gauthier Serge19,Genthon Remy20,Gouw Alida A.621,Habert Marie‐Odile2223,Holtzman David M.2425,Kivipelto Miia2627,Lista Simone2,Molinuevo José‐Luis2829,O'Bryant Sid E.30,Rabinovici Gil D.31,Rowe Christopher32,Salloway Stephen333435,Schneider Lon S.36,Sperling Reisa3738,Teichmann Marc1,Carrillo Maria C.39,Cummings Jeffrey40,Jack Cliff R.41,

Affiliation:

1. Institute of Memory and Alzheimer's Disease (IM2A) and Brain and Spine Institute (ICM) UMR S 1127 Frontlab Department of Neurology, AP_HP Pitié‐Salpêtrière University Hospital, Sorbonne Universities, Pierre et Marie Curie University Paris 06 Paris France

2. AXA Research Fund & UPMC Chair Paris France

3. University of British Columbia Canada

4. Department of Neurology and Alzheimer Center VU University Medical Center and Neuroscience Campus Amsterdam The Netherlands

5. University of Southern California San Diego CA USA

6. UMR1027, INSERM, Université Toulouse III Toulouse University Hospital France

7. IHU‐A‐ICM—Institut des Neurosciences translationnelles de Paris Paris France

8. INSERM U1146—CNRS UMR 7371—UPMC UM CR2, Site Pitié‐Salpêtrière Paris France

9. Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), Institutes of Neurogenetics and Integrative and Experimental Genomics University of Lübeck Lübeck Germany

10. School of Public Health, Faculty of Medicine Imperial College London London UK

11. Clinical Neurochemistry Lab Department of Neuroscience and Physiology University of Gothenburg, Mölndal Hospital, Sahlgrenska University Hospital Mölndal Sweden

12. Federal Institute for Drugs and Medical Devices Bonn Germany

13. Laboratory of Alzheimer's Neuroimaging and Epidemiology IRCCS Centro San Giovanni di Dio Fatebenefratelli Brescia Italy

14. Dementia Research Centre Department of Neurodegenerative Disease, UCL Institute of Neurology University College London London UK

15. INSERM U 1219 Université de Bordeaux France

16. University Pierre et Marie Curie, Assistance Publique des Hôpitaux de Paris Alzheimer‐Prion Team Institut du Cerveau et de la Moelle (ICM) Paris France

17. University Hospitals and University of Geneva Geneva Switzerland

18. IRCCS Fatebenefratelli Brescia Italy

19. McGill Center for Studies in Aging Douglas Mental Health Research Institute Montreal Canada

20. Fondation pour la Recherche sur Alzheimer Hôpital Pitié‐Salpêtrière Paris France

21. Department of Clinical Neurophysiology/MEG Center VU University Medical Center Amsterdam

22. Sorbonne Universités, UPMC Univ Paris 06, CNRS, INSERM Laboratoire d'Imagerie Biomédicale Paris France

23. AP‐HP, Hôpital Pitié‐Salpêtrière Département de Médecine Nucléaire Paris France

24. Department of Neurology Washington University, Hope Center for Neurological Disorders St. Louis MO USA

25. Department of Neurology Washington University, Knight Alzheimer's Disease Research Center St. Louis MO USA

26. Center for Alzheimer Research, Karolinska Institutet Department of Geriatric Medicine Karolinska University Hospital Stockholm Sweden

27. Institute of Clinical Medicine/Neurology University of Eastern Finland Kuopio Finland

28. Alzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clínic Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Barcelona Spain

29. Barcelonaβeta Brain Research Center Pasqual Maragall Foundation Barcelona Spain

30. Center for Alzheimer's & Neurodegenerative Disease Research University of North Texas Health Science Center TX USA

31. Memory & Aging Center Department of Neurology University of California San Francisco San Francisco CA USA

32. Department of Molecular Imaging, Austin Health University of Melbourne Australia

33. Memory and Aging Program, Butler Hospital Alpert Medical School of Brown University USA

34. Department of Neurology Alpert Medical School of Brown University USA

35. Department of Psychiatry Alpert Medical School of Brown University USA

36. Keck School of Medicine of the University of Southern California Los Angeles CA USA

37. Harvard Medical School, Memory Disorders Unit, Center for Alzheimer Research and Treatment Brigham and Women's Hospital Boston USA

38. Harvard Medical School, Memory Disorders Unit, Center for Alzheimer Research and Treatment Massachusetts General Hospital Boston USA

39. The Alzheimer's Association Division of Medical & Scientific Relations Chicago USA

40. Cleveland Clinic Lou Ruvo Center for Brain Health Las Vegas NV USA

41. Department of Radiology Mayo Clinic Rochester MN USA

Funder

AXA Research Fund

National Institute on Aging

Alzheimer's Association

Fondation Université Pierre et Marie Curie

European Medical Information Framework

National Institute on Aging and Alzheimer's Association

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology

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