The path forward in Alzheimer's disease therapeutics: Reevaluating the amyloid cascade hypothesis

Author:

Tolar Martin1,Abushakra Susan1,Sabbagh Marwan2

Affiliation:

1. Alzheon, Inc Framingham MA USA

2. Cleveland Clinic Lou Ruvo Center for Brain Health Las Vegas NV USA

Funder

National Science Foundation

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology

Reference54 articles.

1. Center for Drug Evaluation and Research. 2018 New Drug Therapy Approvals. Available athttps://www.fda.gov/drugs/new‐drugs‐fda‐cders‐new‐molecular‐entities‐and‐new‐therapeutic‐biological‐products/novel‐drug‐approvals‐2018. Accessed June 27 2019.

2. “Biogen Plans Regulatory Filing for Aducanumab in Alzheimer's Disease Based on New Analysis of Larger Dataset from Phase 3 Studies.” Press Release and Company Presentation. October 22 2019.

3. Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease

4. Positron Emission Tomography and Neuropathologic Estimates of Fibrillar Amyloid-β in a Patient With Down Syndrome and Alzheimer Disease

5. Down syndrome and Alzheimer's disease: Common pathways, common goals

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