Cerebrospinal fluid biomarkers of neurodegeneration, synaptic integrity, and astroglial activation across the clinical Alzheimer's disease spectrum

Author:

Bos Isabelle1,Vos Stephanie1,Verhey Frans1,Scheltens Philip2,Teunissen Charlotte3,Engelborghs Sebastiaan456,Sleegers Kristel67,Frisoni Giovanni89,Blin Olivier10,Richardson Jill C.11,Bordet Régis12,Tsolaki Magda13,Popp Julius1415,Peyratout Gwendoline15,Martinez‐Lage Pablo16,Tainta Mikel16,Lleó Alberto17,Johannsen Peter18,Freund‐Levi Yvonne192021,Frölich Lutz22,Vandenberghe Rik23,Westwood Sarah24,Dobricic Valerija25,Barkhof Frederik2627,Legido‐Quigley Cristina2829,Bertram Lars253031,Lovestone Simon24,Streffer Johannes532,Andreasson Ulf3334,Blennow Kaj3334,Zetterberg Henrik33343536,Visser Pieter Jelle12

Affiliation:

1. Alzheimer Centrum LimburgMaastricht UniversityMaastrichtthe Netherlands

2. Alzheimer CenterVU University Medical CenterAmsterdamthe Netherlands

3. Neurochemistry Lab and BiobankDepartment of Clinical ChemistryVU University Medical CenterAmsterdam NeuroscienceAmsterdamthe Netherlands

4. Department of Neurology and Memory ClinicHospital Network Antwerp (ZNA) Middelheim and Hoge BeukenAntwerpBelgium

5. Reference Center for Biological Markers of Dementia (BIODEM)Institute Born‐BungeUniversity of AntwerpAntwerpBelgium

6. Institute Born‐BungeUniversity of AntwerpAntwerpBelgium

7. Neurodegenerative Brain Diseases GroupCenter for Molecular NeurologyVIBAntwerpBelgium

8. University of GenevaGenevaSwitzerland

9. IRCCS Istituto Centro San Giovanni di Dio FatebenefratelliBresciaItaly

10. Mediterranean Institute of Cognitive NeuroscienceAix Marseille UniversityMarseilleFrance

11. Neurosciences Therapeutic AreaGlaxoSmithKline R&DStevenageUK

12. University of LilleInsermCHU LilleLilleFrance

13. 1st Department of NeurologyAHEPA University HospitalMakedoniaThessalonikiGreece

14. Geriatric PsychiatryDepartment of Mental Health and PsychiatryGeneva University HospitalsGenevaSwitzerland

15. Department of PsychiatryUniversity Hospital of LausanneLausanneSwitzerland

16. Department of NeurologyCenter for Research and Advanced TherapiesCITA‐Alzheimer FoundationSan SebastianSpain

17. Hospital de la Santa Creu i Sant PauBarcelonaSpain

18. Danish Dementia Research CentreRigshospitaletCopenhagen University HospitalCopenhagenDenmark

19. Department of NeurobiologyCaring Sciences and Society (NVS)Division of Clinical GeriatricsKarolinska InstitutetStockholmSweden

20. Department of Geriatric MedicineKarolinska University Hospital HuddingeStockholmSweden

21. Department of Psychiatry Norrtälje Hospital TiohundraNorrtäijeSweden

22. Department of Geriatric PsychiatryZentralinstitut für Seelische GesundheitUniversity of HeidelbergMannheimGermany

23. University Hospital LeuvenLeuvenBelgium

24. University of OxfordOxfordUnited Kingdom

25. Lübeck Interdisciplinary Platform for Genome AnalyticsUniversity of LübeckLübeckGermany

26. Department of Radiology and Nuclear MedicineVU University Medical CenterAmsterdamthe Netherlands

27. Institutes of Neurology and Healthcare EngineeringUniversity College LondonLondonUK

28. Steno Diabetes CenterCopenhagenDenmark

29. King's College LondonLondonUK

30. School of Public HealthImperial College LondonLondonUK

31. Department of PsychologyUniversity of OsloOsloNorway

32. Early Clinial NeurologyUCB Biopharma SPRLBraine‐l'AlleudBelgium

33. Clinical Neurochemistry LabInstitute of Neuroscience and PhysiologySahlgrenska University HospitalMölndalSweden

34. Department of Psychiatry and NeurochemistryUniversity of GothenburgInstitute of Neuroscience and PhysiologyMölndalSweden

35. Department of Molecular NeuroscienceUCL Institute of NeurologyLondonUK

36. UK Dementia Research InstituteLondonUK

Funder

European Commission

Roche

Probiodrug

Janssen Prevention Center

Boehringer

Brains Online

Axon Neurosciences

EIP Pharma

Innovative Medicines Initiative

Seventh Framework Program

EFPIA

Department of Health of the Basque Government

Swiss National Research Foundation

University of Antwerp Research Fund

NIHR UCLH biomedical research center

Department of Economic Promotion, Rural Areas and Territorial Balance of the Provincial Government of Gipuzkoa

Department of Health of the Basque Government

Carlos III Institute of Health

Obra Social Kutxa-Fundazioa

Dutch Research Council (ZonMW)

Alzheimer's Drug Discovery Foundation

Alzheimer Netherlands

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Clinical Neurology,Developmental Neuroscience,Health Policy,Epidemiology

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