Mutation-Induced Population Shift in the MexR Conformational Ensemble Disengages DNA Binding: A Novel Mechanism for MarR Family Derepression-Reference-Cited by-同舟云学术

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Mutation-Induced Population Shift in the MexR Conformational Ensemble Disengages DNA Binding: A Novel Mechanism for MarR Family Derepression

Published:2016-08 Issue:8 Volume:24 Page:1311-1321
ISSN:0969-2126
Container-title:Structure
language:en
Short-container-title:Structure

Author:

Anandapadamanaban Madhanagopal,Pilstål Robert,Andresen Cecilia,Trewhella Jill,Moche Martin,Wallner Björn,Sunnerhagen Maria

Funder

European Community's Seventh Framework Program

Swedish e-Science Research Center

Swedish Research Council

Swedish National Infrastructure for Computing

Publisher

Elsevier BV

Reference59 articles.

1. The mexR repressor of the mexAB-oprM multidrug efflux operon in Pseudomonas aeruginosa: characterization of mutations compromising activity;Adewoye;J. Bacteriol.,2002

2. Mutational analysis of MarR, the negative regulator of marRAB expression in Escherichia coli, suggests the presence of two regions required for DNA binding;Alekshun;Mol. Microbiol.,2000

3. The crystal structure of MarR, a regulator of multiple antibiotic resistance, at 2.3 A resolution;Alekshun;Nat. Struct. Biol.,2001

4. Emergence of symmetry in homooligomeric biological assemblies;André;Proc. Natl. Acad. Sci. USA,2008

5. Critical biophysical properties in the Pseudomonas aeruginosa efflux gene regulator MexR are targeted by mutations conferring multidrug resistance;Andrésen;Protein Sci.,2010

Cited by 18 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Efflux pumps of Pseudomonas aeruginosa and their regulatory mechanisms underlying multidrug resistance;International Biodeterioration & Biodegradation;2025-06

2. Crystal structure of a Clostridioides difficile multiple antibiotic resistance regulator (MarR) CD0473 suggests a potential redox-regulated function;International Journal of Biological Macromolecules;2024-11

3. Mutation Analysis in Regulator DNA-Binding Regions for Antimicrobial Efflux Pumps in 17,000 Pseudomonas aeruginosa Genomes;Microorganisms;2023-10-04

4. The culmination of multidrug-resistant efflux pumps vs. meager antibiotic arsenal era: Urgent need for an improved new generation of EPIs;Frontiers in Microbiology;2023-04-17

5. Small-angle x-ray and neutron scattering of MexR and its complex with DNA supports a conformational selection binding model;Biophysical Journal;2023-01

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