The HisRS-like domain of GCN2 is a pseudoenzyme that can bind uncharged tRNA-Reference-Cited by-同舟云学术

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The HisRS-like domain of GCN2 is a pseudoenzyme that can bind uncharged tRNA

Published:2024-06 Issue:6 Volume:32 Page:795-811.e6
ISSN:0969-2126
Container-title:Structure
language:en
Short-container-title:Structure

Author:

Yin Jay Z.,Keszei Alexander F.A.,Houliston Scott,Filandr Frantisek,Beenstock Jonah,Daou Salima,Kitaygorodsky Julia,Schriemer David C.,Mazhab-Jafari Mohammad T.,Gingras Anne-Claude,Sicheri Frank^ORCID

Funder

CIHR

Publisher

Elsevier BV

Reference71 articles.

1. Translational regulation of GCN4 and the general amino acid control of yeast;Hinnebusch;Annu. Rev. Microbiol.,2005

2. The integrated stress response: From mechanism to disease;Costa-Mattioli;Science,2020

3. An integrated stress response regulates amino acid metabolism and resistance to oxidative stress;Harding;Mol. Cell,2003

4. Differential requirements for P stalk components in activating yeast protein kinase Gcn2 by stalled ribosomes during stress;Gupta;Proc. Natl. Acad. Sci. USA,2023

5. Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast;Dever;Cell,1992

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Gcn2 structurally mimics and functionally repurposes the HisRS enzyme for the integrated stress response;Proceedings of the National Academy of Sciences;2024-08-20

2. Paradoxical Activation of GCN2 by ATP-competitive inhibitors via allosteric activation and autophosphorylation;2024-08-14

3. Trading in catalytic power for sensing;Structure;2024-06

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