Tissue distribution and mode of DNA methylation in mice by methyl methanesulphonate and N-methyl-N′-nitro-N-nitrosoguanidine: Lack of thymic lymphoma induction and low extent of methylation of target tissue DNA at O-6 of guanine

Author:

Frei J.V.,Lawley P.D.

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference13 articles.

1. Tumour induction by low molecular weight alkylating agents;Frei;Chem.-Biol. Interact.,1971

2. Effect of dose and schedule of MNUA on incidence of malignant lymphoma in adult female mice;Joshi;J. Natl. Cancer Inst.,1970

3. Methylation of DNA in various organs of C57BL mice by a carcinogenic dose of MNUA and stability of some methylation products up to 18 hours;Frei;Chem.-Biol. Interact.,1975

4. J.V. Frei and P.D. Lawley, unpublished data.

5. Organ-specific effects of DNA methylation by alkylating agents in the inbred Swiss mouse;Maitra;Chem.-Biol. Interact,1975

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