INS-gene mutations: From genetics and beta cell biology to clinical disease

Author:

Liu Ming,Sun Jinhong,Cui Jinqiu,Chen Wei,Guo Huan,Barbetti Fabrizio,Arvan Peter

Funder

NIH

National Natural Science Foundation of China

University of Michigan Medical School

Tianjin Scientific and Technical Committee

Novo Nordisk β-cell Academy

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Molecular Biology,Molecular Medicine,General Medicine,Biochemistry

Reference173 articles.

1. The biosynthesis of the subtilisin-related proprotein convertase PC3, but no that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets;Alarcón;J. Biol. Chem,1993

2. Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus;Alarcon;J. Clin. Invest,1995

3. High ER stress in β-cells stimulates intracellular degradation of misfolded insulin;Allen;Biochem. Biophys. Res. Commun,2004

4. Mutation of the signal peptide-encoding region of the preproparathyroid hormone gene in familial isolated hypoparathyroidism;Arnold;J. Clin. Invest,1990

5. [LeuB24]insulin and [AlaB24]insulin: altered structures and cellular processing of B24-substituted insulin analogs;Assoian;Proc. Natl. Acad. Sci. U.S.A.,1982

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