Why is PAK4 overexpressed in cancer?

Author:

Costa Tânia D.F.ORCID,Strömblad StaffanORCID

Funder

Swedish Research Council

Swedish Cancer Society

Publisher

Elsevier BV

Subject

Cell Biology,Biochemistry

Reference75 articles.

1. PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia;Abo;EMBO J.,1998

2. Novel p21-activated kinase 4 (PAK4) Allosteric modulators overcome drug resistance and stemness in pancreatic ductal adenocarcinoma;Aboukameel;Mol. Cancer Ther.,2017

3. PAK4 inhibition improves PD-1 blockade immunotherapy;Abril-Rodriguez;Nat. Cancer,2020

4. Dual and specific inhibition of NAMPT and PAK4 by KPT-9274 decreases kidney cancer growth;Abu Aboud;Mol. Cancer Ther.,2016

5. P21-activated kinase 4 overexpression in metastatic gastric cancer patients;Ahn;Transl. Oncol.,2011

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