The use of virtual screening and differential scanning fluorimetry for the rapid identification of fragments active against MEK1-Reference-Cited by-同舟云学术

The use of virtual screening and differential scanning fluorimetry for the rapid identification of fragments active against MEK1

Published:2013-06 Issue:12 Volume:23 Page:3620-3626
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Amaning Kwame,Lowinski Maryse,Vallee Francois,Steier Valerie,Marcireau Christophe,Ugolini Antonio,Delorme Cecile,Foucalt Frédéric,McCort Gary,Derimay Nathalie,Andouche Cyrielle,Vougier Stephanie,Llopart Sylvie,Halland Nis,Rak Alexey

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference34 articles.

1. Molecular Complexity and Its Impact on the Probability of Finding Leads for Drug Discovery

2. Transforming fragments into candidates: small becomes big in medicinal chemistry

3. Fragment-based lead discovery grows up

4. Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

5. Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

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