Phthalazinones 2: Optimisation and synthesis of novel potent inhibitors of poly(ADP-ribose)polymerase-Reference-Cited by-同舟云学术

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Phthalazinones 2: Optimisation and synthesis of novel potent inhibitors of poly(ADP-ribose)polymerase

Published:2006-02 Issue:4 Volume:16 Page:1040-1044
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Cockcroft Xiao-ling,Dillon Krystyna J.,Dixon Lesley,Drzewiecki Jan,Kerrigan Frank,Loh Vincent M.,Martin Niall M.B.,Menear Keith A.,Smith Graeme C.M.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference12 articles.

1. Role of poly(ADP-ribose) formation in DNA repair

2. Endothelial dysfunction in a rat model of endotoxic shock. Importance of the activation of poly (ADP-ribose) synthetase by peroxynitrite.

3. Hydrogen peroxide insult in cultured mammalian cells: relationships between DNA single-strand breakage, poly(ADP-ribose) metabolism and cell killing

4. PARP inhibitors for cancer therapy

5. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

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