4-Methyl-1,2,4-triazol-3-yl heterocycle as an alternative to the 1-methylimidazol-5-yl moiety in the Farnesyltransferase inhibitor ZARNESTRA ™-Reference-Cited by-同舟云学术

4-Methyl-1,2,4-triazol-3-yl heterocycle as an alternative to the 1-methylimidazol-5-yl moiety in the Farnesyltransferase inhibitor ZARNESTRA ™

Published:2003-12 Issue:24 Volume:13 Page:4361-4364
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Angibaud Patrick,Saha Ashis K.,Bourdrez Xavier,End David W.,Freyne Eddy,Lezouret Patricia,Mannens Geert,Mevellec Laurence,Meyer Christophe,Pilatte Isabelle,Poncelet Virginie,Roux Bruno,Smets Gerda,Van Dun Jacky,Venet Marc,Wouters Walter

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference29 articles.

1. ras GENES

2. p21ras is modified by a farnesyl isoprenoid.

3. Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity.

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