Design, synthesis and structure activity relationships of indazole and indole derivatives as potent glucagon receptor antagonists

Author:

Song FengbinORCID,Xu Guozhang,Gaul Michael D.,Zhao Baoping,Lu Tianbao,Zhang Rui,DesJarlais Renee L.,DiLoreto Karen,Huebert Norman,Shook Brian,Rentzeperis Dennis,Santulli Rosie,Eckardt Annette,Demarest Keith

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference35 articles.

1. Documentation of hyperglucagonemia throughout the day in nonobese and obese patients with noninsulin-dependent diabetes mellitus;Reaven;J Clin Endocrinol Metab,1987

2. Lack of suppression of glucagon contributes to postprandial hyperglycemia in subjects with type 2 diabetes mellitus;Shah;J Clin Endocrinol Metab,2000

3. CP-99,711: a non-peptide glucagon receptor antagonist;Collins;Bioorg Med Chem Lett,1992

4. Discovery and structure–activity relationship of the first non-peptide competitive human glucagon receptor antagonists;Madsen;J Med Chem,1998

5. Potent, orally absorbed glucagon receptor antagonists;de Laszlo;Bioorg Med Chem Lett,1999

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