Disubstituted pyrimidines as Lck inhibitors-Reference-Cited by-同舟云学术

Disubstituted pyrimidines as Lck inhibitors

Published:2009-09 Issue:18 Volume:19 Page:5440-5443
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Hunt Julianne A.,Beresis Richard T.,Goulet Joung L.,Holmes Mark A.,Hong Xinfang J.,Kovacs Ernest,Mills Sander G.,Ruzek Rowena D.,Wong Frederick,Hermes Jeffrey D.,Park Young-Whan,Salowe Scott P.,Sonatore Lisa M.,Wu Lin,Woods Andrea,Zaller Dennis M.,Sinclair Peter J.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference10 articles.

1. DIFFERENTIAL SIGNALING BY LYMPHOCYTE ANTIGEN RECEPTORS

2. LEUKOCYTE PROTEIN TYROSINE KINASES:Potential Targets for Drug Discovery

3. The Role of Protein Tyrosine Kinases and Protein Tyrosine Phosphatases in T Cell Antigen Receptor Signal Transduction

4. Structure-Based Design of Novel 2-Amino-6-phenyl-pyrimido[5′,4′:5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as Potent and Orally Active Inhibitors of Lymphocyte Specific Kinase (Lck): Synthesis, SAR, and In Vivo Anti-Inflammatory Activity

5. Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection

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