Application of a UPLC–MS/MS method to the protein binding study of TM-2 in rat, human and beagle dog plasma

Author:

Liu Hui,Wu Pan-Pan,Yang Ming-Jing,Men Lei,Lin Hong-Li,Zhao Yun-Li,Tang Xing,Yu Zhi-Guo

Funder

National High Technology Research and Development Program of China

Publisher

Elsevier BV

Subject

Analytical Chemistry,Electrochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Pharmacy

Reference20 articles.

1. Molecular-targeted therapy;Tamura;Gan To Kagaku Ryoho,2003

2. Y.X. Li, M.Y. Geng, J.F. Wang, et al., Multi-drug resistant derivatives and its preparation method and application of taxanes, China Patent no. 201110127602.X, 2011-05-17.

3. Preformulation and development of chemically stable lipid emulsions containing a novel taxane derivative, TM-2;Shi;Eur. J. Lipid Sci. Technol.,2014

4. Development of a rapid and sensitive UPLC–MS/MS assay for the determination of TM-2 in beagle dog plasma and its application to a pharmacokinetic study;Lin;Biomed. Chromatogr.,2015

5. Metabolism of TM-2, a potential antitumor drug, in rats by using LC–MS;Lei;J. Sep. Sci.,2014

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