Structure-based discovery of orally efficient inhibitors via unique interactions with H-pocket of PDE8 for the treatment of vascular dementia
Author:
Publisher
Elsevier BV
Subject
General Pharmacology, Toxicology and Pharmaceutics
Reference41 articles.
1. Vascular dementia;O'Brien;Lancet,2015
2. Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for Alzheimer's disease;Kalaria;Acta Neuropathol,2016
3. Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging;Wardlaw;Lancet Neurol,2013
4. Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory;Abel;Cell,1997
5. Amyloid beta-peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling;Vitolo;Proc Natl Acad Sci U S A,2002
Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Targeting the blood–brain barrier to delay aging-accompanied neurological diseases by modulating gut microbiota, circadian rhythms, and their interplays;Acta Pharmaceutica Sinica B;2023-12
2. Targeting Striatal Glutamate and Phosphodiesterases to Control L-DOPA-Induced Dyskinesia;Cells;2023-11-30
3. Combination of QTL and GWAS to uncover the role of phosphodiesterases in ischemic heart disease;2023-09-25
4. Discovery of novel phosphodiesterase-1 inhibitors for curing vascular dementia: Suppression of neuroinflammation by blocking NF-κB transcription regulation and activating cAMP/CREB axis;Acta Pharmaceutica Sinica B;2023-03
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"全球学者库"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前全球学者库共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2023 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3