A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice

Author:

Laczkó Dorottya,Hogan Michael J.ORCID,Toulmin Sushila A.,Hicks PhilipORCID,Lederer KatlynORCID,Gaudette Brian T.,Castaño Diana,Amanat Fatima,Muramatsu Hiromi,Oguin Thomas H.,Ojha AmritaORCID,Zhang Lizhou,Mu ZekunORCID,Parks Robert,Manzoni Tomaz B.ORCID,Roper BrianneORCID,Strohmeier Shirin,Tombácz István,Arwood LesleeORCID,Nachbagauer Raffael,Karikó Katalin,Greenhouse Jack,Pessaint LaurentORCID,Porto Maciel,Putman-Taylor TammyORCID,Strasbaugh AmandaORCID,Campbell Tracey-Ann,Lin Paulo J.C.ORCID,Tam Ying K.,Sempowski Gregory D.,Farzan Michael,Choe Hyeryun,Saunders Kevin O.ORCID,Haynes Barton F.,Andersen Hanne,Eisenlohr Laurence C.,Weissman Drew,Krammer Florian,Bates PaulORCID,Allman David,Locci Michela,Pardi Norbert

Funder

National Heart, Lung, and Blood Institute

National Institutes of Health

Publisher

Elsevier BV

Subject

Infectious Diseases,Immunology,Immunology and Allergy

Reference42 articles.

1. Messenger RNA-Based Vaccines Against Infectious Diseases;Alameh;Curr. Top. Microbiol. Immunol.,2020

2. SARS-CoV-2 Vaccines: Status Report;Amanat;Immunity,2020

3. A serological assay to detect SARS-CoV-2 seroconversion in humans;Amanat;medRxiv,2020

4. Nucleoside-modified mRNA encoding HSV-2 glycoproteins C, D, and E prevents clinical and subclinical genital herpes;Awasthi;Sci. Immunol.,2019

5. Preclinical and Clinical Demonstration of Immunogenicity by mRNA Vaccines against H10N8 and H7N9 Influenza Viruses;Bahl;Mol. Ther.,2017

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