Integrating transcriptomics, metabolomics, and GWAS helps reveal molecular mechanisms for metabolite levels and disease risk-Reference-Cited by-同舟云学术

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Integrating transcriptomics, metabolomics, and GWAS helps reveal molecular mechanisms for metabolite levels and disease risk

Published:2022-10 Issue:10 Volume:109 Page:1727-1741
ISSN:0002-9297
Container-title:The American Journal of Human Genetics
language:en
Short-container-title:The American Journal of Human Genetics

Author:

Yin Xianyong^ORCID,Bose Debraj,Kwon Annie,Hanks Sarah C.,Jackson Anne U.,Stringham Heather M.,Welch Ryan,Oravilahti Anniina,Fernandes Silva Lilian,Locke Adam E.,Fuchsberger Christian,Service Susan K.,Erdos Michael R.,Bonnycastle Lori L.,Kuusisto Johanna,Stitziel Nathan O.,Hall Ira M.,Morrison Jean,Ripatti Samuli,Palotie Aarno,Freimer Nelson B.,Collins Francis S.,Mohlke Karen L.,Scott Laura J.,Fauman Eric B.,Burant Charles,Boehnke Michael,Laakso Markku,Wen Xiaoquan

Funder

National Institutes of Health

American Diabetes Association

National Human Genome Research Institute

Pfizer

Sigrid Juséliuksen Säätiö

Horizon 2020

Regeneron Pharmaceuticals

Academy of Finland

Sydäntutkimussäätiö

University of Michigan

Helsingin Yliopisto

Publisher

Elsevier BV

Subject

Genetics (clinical),Genetics

Reference69 articles.

1. 15 years of genome-wide association studies and no signs of slowing down;Loos;Nat. Commun.,2020

2. Recent innovations and in-depth aspects of post-genome wide association study (Post-GWAS) to understand the genetic basis of complex phenotypes;Mortezaei;Heredity,2021

3. From GWAS to gene: transcriptome-wide association studies and other methods to functionally understand GWAS discoveries;Li;Front. Genet.,2021

4. From GWAS to function: using functional genomics to identify the mechanisms underlying complex diseases;Cano-Gamez;Front. Genet.,2020

5. A multi-omic integrative scheme characterizes tissues of action at loci associated with type 2 diabetes;Torres;Am. J. Hum. Genet.,2020

Cited by 21 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Transcriptomics integrated with metabolomics reveals partial molecular mechanisms of nutritional risk and neurodevelopment in children with congenital heart disease;Frontiers in Cardiovascular Medicine;2024-08-09

2. Metabolic gene function discovery platform GeneMAP identifies SLC25A48 as necessary for mitochondrial choline import;Nature Genetics;2024-07-08

3. Transcriptomic and Metabolomic analyses in Monozygotic and Dizygotic twins;2024-06-26

4. Technological advancements in functional interpretation of genome‐wide association studies (GWAS) findings: bridging the gap to clinical translation;FEBS Letters;2024-04-29

5. Integrative analysis of the genome, transcriptome, and proteome identifies causal mechanisms of complex traits;2024-03-31

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