Effects of N-methylmercaptoimidazole on the disposition of MPTP and its metabolites in mice

Author:

Chiba Kan,Horii Hidekazu,Kubota Emi,Ishizaki Takashi,Kato Yuriko

Publisher

Elsevier BV

Subject

Pharmacology

Reference23 articles.

1. 1-Methyl-4-phenylpyridine is neurotoxic to the nigrostriatal dopamine pathway;Bradbury;Nature,1986

2. A primate model of parkinsonism: Selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by MPTP;Burns,1983

3. Contribution of N-oxygenation of the metabolism of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) by various liver preparations;Cashman;Mol. Pharmacol.,1986

4. Characterization of hepatic microsomal metabolism as an in vivo detoxication pathway of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice;Chiba;J. Pharmacol. Exp. Ther.,1988

5. Studies on the molecular mechanism of bioactivation of the selective nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP);Chiba;Drug Metab. Dispos.,1985

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