Immunoediting of KEAP1-NRF2 mutant tumours is required to circumvent NRF2-mediated immune surveillance
Author:
Funder
Japan Society for the Promotion of Science London
Japan Society for the Promotion of Science
Japan Agency for Medical Research and Development
Publisher
Elsevier BV
Subject
Organic Chemistry,Biochemistry,Clinical Biochemistry
Reference66 articles.
1. The KEAP1-NRF2 system: a thiol-based sensor-effector apparatus for maintaining redox homeostasis;Yamamoto;Physiol. Rev.,2018
2. Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases;Cuadrado;Nat. Rev. Drug Discov.,2019
3. An nrf2/small maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements;Itoh;Biochem. Biophys. Res. Commun.,1997
4. Role of chemopreventive phytochemicals in NRF2-mediated redox homeostasis in humans;Chun;Free Radic. Biol. Med.,2021
5. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain;Itoh;Gene Dev.,1999
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