Hemoglobin is an oxygen-dependent glutathione buffer adapting the intracellular reduced glutathione levels to oxygen availability

Author:

Fenk Simone,Melnikova Elizaveta V.,Anashkina Anastasia A.,Poluektov Yuri M.,Zaripov Pavel I.,Mitkevich Vladimir A.,Tkachev Yaroslav V.,Kaestner Lars,Minetti Giampaolo,Mairbäurl Heimo,Goede Jeroen S.,Makarov Alexander A.,Petrushanko Irina Yu,Bogdanova AnnaORCID

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Universität Zürich

Russian Science Foundation

National Science Foundation

Horizon 2020

Deutsche Forschungsgemeinschaft

Publisher

Elsevier BV

Subject

Organic Chemistry,Biochemistry,Clinical Biochemistry

Reference62 articles.

1. Redox imbalance, macrocytosis, and RBC homeostasis;Tsantes;Antioxidants Redox Signal.,2006

2. Inborn defects in the antioxidant systems of human red blood cells;Van Zwieten;Free Radic. Biol. Med.,2014

3. Oxidative stress and thrombosis during aging: the roles of oxidative stress in RBCs in venous thrombosis;Wang;Int. J. Mol. Sci.,2020

4. S-glutathionylation: from molecular mechanisms to health outcomes;Xiong;Antioxidants Redox Signal.,2011

5. Membrane skeletal protein S-glutathionylation and hemolysis in human red blood cells;Rossi;Blood Cells Mol. Dis.,2006

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