Brain ischemic preconditioning protects against ischemic injury and preserves the blood-brain barrier via oxidative signaling and Nrf2 activation

Author:

Yang Tuo,Sun Yang,Mao Leilei,Zhang Meijuan,Li Qianqian,Zhang Lili,Shi YejieORCID,Leak Rehana K.,Chen Jun,Zhang Feng

Funder

US National Institutes of Health

Veterans Affairs

American Heart Association

National Natural Science Foundation of China

Publisher

Elsevier BV

Subject

Organic Chemistry,Biochemistry,Clinical Biochemistry

Reference74 articles.

1. Sulforaphane preconditioning of the Nrf2/HO-1 defense pathway protects the cerebral vasculature against blood-brain barrier disruption and neurological deficits in stroke;Alfieri;Free Radic. Biol. Med.,2013

2. The protective effects of preconditioning on cerebral endothelial cells in vitro;Andjelkovic;J. Cereb. Blood Flow Metab.,2003

3. The cytoprotective role of the Keap1-Nrf2 pathway;Baird;Arch. Toxicol.,2011

4. Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex;Baird;Proc. Natl. Acad. Sci. USA,2013

5. Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning;Bell;Proc. Natl. Acad. Sci. USA,2011

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