Identification of inhibitors targeting polyketide synthase 13 of Mycobacterium tuberculosis as antituberculosis drug leads-Reference-Cited by-同舟云学术

Identification of inhibitors targeting polyketide synthase 13 of Mycobacterium tuberculosis as antituberculosis drug leads

Published:2021-09 Issue: Volume:114 Page:105110
ISSN:0045-2068
Container-title:Bioorganic Chemistry
language:en
Short-container-title:Bioorganic Chemistry

Author:

Wang Xiao,Zhao Wenting,Wang Bin,Ding Wei,Guo Hao,Zhao Hongyi,Meng Jianzhou,Liu Sihan,Lu Yu,Liu Yishuang,Zhang Dongfeng

Funder

Chinese Academy of Meteorological Sciences

Chinese Academy of Medical Sciences & Peking Union Medical College

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry

Reference22 articles.

1. Global tuberculosis report 2020. Geneva: World Health Organization, 2020. https://apps.who.int/iris/handle/10665/336069 (accessed 173 October 2020).

2. A polyketide synthase catalyzes the last condensation step of mycolic acid biosynthesis in mycobacteria and related organisms;Portevin;Proc. Natl. Acad. Sci. U.S.A.,2004

3. The Pks13/FadD32 crosstalk for the biosynthesis of mycolic acids in Mycobacterium tuberculosis;Gavalda;J. Biol. Chem.,2009

4. The polyketide synthase Pks13 catalyzes a novel mechanism of lipid transfer in mycobacteria;Gavalda;Chem. Biol.,2014

5. Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis;Wilson;Nat. Chem. Biol.,2013

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1. Targeting polyketide synthase 13 for the treatment of tuberculosis;European Journal of Medicinal Chemistry;2023-11

2. Pathogenic mycobacteria suppress host antimicrobial peptides by dehydrogenating L-alanine;2023-09-22

3. Pks 13 inhibitors—a promising target for future antitubercular agents;Medicinal Chemistry Research;2023-06-17

4. Computational characteristics of the structure-activity relationship of inhibitors targeting Pks13-TE domain;Computational Biology and Chemistry;2023-06

5. Advances in computational frameworks in the fight against TB: The way forward;Frontiers in Pharmacology;2023-04-03