Discovery and optimization of 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one derivatives as mTORC1/mTORC2 dual inhibitors-Reference-Cited by-同舟云学术

Discovery and optimization of 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one derivatives as mTORC1/mTORC2 dual inhibitors

Published:2019-11 Issue: Volume:92 Page:103232
ISSN:0045-2068
Container-title:Bioorganic Chemistry
language:en
Short-container-title:Bioorganic Chemistry

Author:

Hu Shengquan,Zhao Zhichang,Yan Hong

Funder

Beijing Natural Science Foundation

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry

Reference33 articles.

1. The emerging role of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling network in normal myelopoiesis and leukemogenesis;Martelli;Cancers,1803

2. Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination;Yu;Development,2016

3. mTOR signaling in growth, metabolism, and disease;Saxton;Cell,2017

4. mTOR kinase structure, mechanism and regulation;Yang;Nature,2013

5. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery;Kim;Cell,2002

Cited by 8 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Synthesis, Characterization, Antimicrobial, and Molecular Docking Studies of Thiazolidin-4-one Derivatives fused with Indole and Pyrimidine Moieties;Russian Journal of Bioorganic Chemistry;2023-11

2. POCl₃ mediated one-pot deoxygenative aromatization and electrophilic chlorination of dihydroxy-2-methyl-4-oxo-indeno[1,2-b]pyrroles;RSC Advances;2023

3. An Approach to Pharmacological Targets of Pyrrole Family From Medicinal Chemistry Viewpoint;Mini-Reviews in Medicinal Chemistry;2022-10

4. Synthesis, Characterization, Biological, and Molecular Docking Studies of (Z)-N-Substituted-4-(Pyridin-2-yl)-6-(1H-Pyrrolo[2,3-b]Pyridin-4-yl)Pyrimidin-2-Amine;Russian Journal of Bioorganic Chemistry;2022-07-28

5. Phenotypical screening on metastatic PRCC-TFE3 fusion translocation renal cell carcinoma organoids reveals potential therapeutic agents;Clinical and Translational Oncology;2022-02-03