(+)-Isocryptotanshinone derivatives and its simplified analogs as STAT3 signaling pathway inhibitors

Author:

Shi Xiang,Du Ting ting,Zhang Zhihui,Liu Xiaoyu,Yang Ying,Xue Nina,Jiao Xiaozhen,Chen Xiaoguang,Xie Ping

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry

Reference22 articles.

1. STAT3 localizes to the ER, acting as a gatekeeper for ER-mitochondrion Ca2+ fluxes and apoptotic responses;Avalle;Cell Death Differ.,2019

2. Activation of STAT3 in human gastric cancer cells via interleukin (IL)-6-type cytokine signaling correlates with clinical implications;Wang;PLoS ONE,2013

3. Inhibition of the STAT3 signaling pathway contributes to apigenin-mediated anti-metastatic effect in melanoma;Cao;Sci. Rep.,2016

4. Inhibition of STAT3 activity re-activates anti-tumor immunity but fails to restore the immunogenicity of tumor cells in a B-cell lymphoma model;Cao;Cancer Biol. Ther.,2014

5. A natural product-like JAK2/STAT3 inhibitor induces apoptosis of malignant melanoma cells;Wu;PLoS ONE,2017

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