Design, synthesis, in vitro antiproliferative evaluation and in silico studies of new VEGFR-2 inhibitors based on 4-piperazinylquinolin-2(1H)-one scaffold

Author:

Hassan Abdelfattah,Badr Mohamed,Abdelhamid Dalia,Hassan Heba A.,Abourehab Mohammed A.S.,Abuo‐Rahma Gamal El‐Din A.

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry

Reference30 articles.

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2. World Health Organization Fact Sheets. https://www.who.int/news-room/fact-sheets/detail/cancer (accessed July 1, 2021).

3. InternationalAgency for Research on Cancer. https://gco.iarc.fr/today/home (accessed July 1, 2021).

4. Vascular Endothelial Growth Factor Receptor (VEGFR-2)/KDR Inhibitors: Medicinal Chemistry Perspective;Modi;Med. Drug Discov.,2019

5. Discovery of VEGFR-2 inhibitors exerting significant anticancer activity against CD44+ and CD133+ cancer stem cells (CSCs): Reversal of TGF-β induced epithelial-mesenchymal transition (EMT) in hepatocellular carcinoma;Modi;Eur. J. Med. Chem.,2020

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