Selective and antagonist-dependent µ-opioid receptor activation by the combination of 2-{[2-(6-chloro-3,4-dihydro-1(2H)-quinolinyl)-2-oxoethyl]sulfanyl}-5-phenyl-4,6-(1H,5H)-pyrimidinedione and naloxone/naltrexone

Author:

Lin Shu-Yu,Tien Ya-Wen,Ke Yi-Yu,Chang Yung-Chiao,Chang Hsiao-Fu,Ou Li-Chin,Law Ping-Yee,Xi Jing-Hua,Tao Pao-Luh,Loh Horace H.,Chao Yu-Sheng,Shih Chuan,Chen Chiung-Tong,Yeh Shiu-Hwa,Ueng Shau-HuaORCID

Funder

National Health Research Institutes

National Tsing Hua University

Ministry of Science and Technology, Taiwan

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry

Reference27 articles.

1. Opioid receptors;Waldhoer;Annu. Rev. Biochem.,2004

2. Search for the “ideal analgesic” in pain treatment by engineering the mu-opioid receptor;Tao;IUBMB Life,2010

3. Opioid elevation of intracellular free calcium: possible mechanisms and physiological relevance;Samways;Cell Signal,2006

4. Cellular and synaptic adaptations mediating opioid dependence;Williams;Physiol. Rev.,2001

5. Molecular mechanisms of opioid receptor-dependent signaling and behavior;Al-Hasani;Anesthesiology,2011

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