Natural carbazole alkaloid murrayafoline A displays potent anti-neuroinflammatory effect by directly targeting transcription factor Sp1 in LPS-induced microglial cells
Author:
Funder
Key Technology Research and Development Program of Shandong
National Natural Science Foundation of China
Peking University Health Science Center
Publisher
Elsevier BV
Subject
Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry
Reference42 articles.
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2. Nerve growth factor induces transcription of the p21 WAF1/CIP1 and cyclin D1 genes in PC12 cells by activating the Sp1 transcription factor;Yan;J. Neurosci.,1997
3. MiR-29c protects against inflammation and apoptosis in Parkinson's disease model in vivo and in vitro by targeting SP1;Wang;Clin. Exp. Pharmacol. Physiol.,2020
4. H.J. An, H.J. Lee, S. Jang, Y.J. Jung, S.S. Choi, S.C. Park, J.A. Han, Transcription factor Sp1 prevents TRF2(ΔBΔM)-induced premature senescence in human diploid fibroblasts, Mol. Cell. Biochem. 414(1-2) (2016) 201–208, https:// doi.org/10.1007/s11010-016-2672-7.
5. MicroRNA-124-3p attenuates myocardial injury in sepsis via modulating SP1/HDAC4/HIF-1α axis;Wu;Cell Death Discov.,2022
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