Synthesis by diastereomeric resolution, biochemical evaluation and molecular modelling of chiral 3-hydroxyl b-lactam microtubule-targeting agents for the treatment of triple negative breast and chemoresistant colorectal cancers

Author:

McLoughlin Eavan C.,Twamley Brendan,O'Brien John E.,Hannon Barroeta Patricia,Zisterer Daniela M.,Meegan Mary J.,O'Boyle Niamh M.

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry

Reference97 articles.

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2. β-Lactam analogues of combretastatin A-4 prevent metabolic inactivation by glucuronidation in chemoresistant HT-29 colon cancer cells;Malebari;Eur. J. Med. Chem.,2017

3. ICH, ICH Topic Q 6 A Specifications: Test Procedures and Acceptance Criteria for New Drug Substances and New Drug Products: Chemical Substances In Q 6 A, EMA, Ed. EMA: London, 1999; Vol. CPMP/ICH/367/96) pp 2-32.

4. EMA, Investigation of Chiral Active Substances. In 3CC29a EMA, Ed. EMA: London, 1993; Vol. 75/318/EEC pp 381-391.

5. WHO Breast cancer. https://www.who.int/news-room/fact-sheets/detail/breast-cancer (accessed 7-2-22).

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