Structurally modified Cyclovirobuxine-D Buxus alkaloids as effective analgesic agents through Cav3.2 T-Type calcium channel inhibition

Author:

Munikishore Rachakunta,Liu Rui,Zhang Shuqun,Zhao Qin-Shi,Nian Yin,Zuo ZhiliORCID

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry

Reference43 articles.

1. K.S. Brown, S.M. Kupchan, Buxus alkaloids. VI. The constitution of Cyclovirobuxine-D, Tetrahedron Lett. 5 (1964) 2895–2900.

2. L.Z. Wang, W.D. Shan. The isolation and identification of Cyclovirobuxine D from Buxus microphylla Sieb. Zucc. var. sinica Rehd. et Wils (Xiaoyehuangyang), Study Chin Tradit Pat Med. 4 (1979) 24–26.

3. Atta-ur-Rahman, 4,4,14-Trimethyl-3[alpha],20-bis(methylamino)-9,19-cyclo-5[alpha]-pregnan-16-ol;Choudhary;Acta Cryst. E.,2003

4. Chemistry and Biological Activities of Buxus Alkaloids;Yan;Curr. Bioact. Compd.,2011

5. Cyclovirobuxine;He,2018

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