Battling colorectal cancer via s-triazine-based MMP-10/13 inhibitors armed with electrophilic warheads for concomitant ferroptosis induction; the first-in-class dual-acting agents

Author:

Morcos Christine A.,Khattab Sherine N.,Haiba Nesreen S.,Bassily Rafik W.,Abu-Serie Marwa M.,Teleb MohamedORCID

Funder

Science and Technology Development Fund

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry

Reference93 articles.

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2. Global colorectal cancer burden in 2020 and projections to 2040;Xi;Transl. Oncol.,2021

3. Treatment decisions in metastatic colorectal cancer – Beyond first and second line combination therapies;Vogel;Cancer Treat. Rev.,2017

4. Hybrid Molecules with a Dual Mode of Action: Dream or Reality?;Meunier;Acc. Chem. Res.,2008

5. First-in-Class Dual Mechanism Ferroptosis-HDAC Inhibitor Hybrids;Karaj;J. Med. Chem.,2022

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