Design, synthesis and biological evaluation of purine-based derivatives as novel JAK2/BRD4(BD2) dual target inhibitors-Reference-Cited by-同舟云学术

Design, synthesis and biological evaluation of purine-based derivatives as novel JAK2/BRD4(BD2) dual target inhibitors

Published:2023-03 Issue: Volume:132 Page:106386
ISSN:0045-2068
Container-title:Bioorganic Chemistry
language:en
Short-container-title:Bioorganic Chemistry

Author:

Guo Yong,Zou Yurong,Chen Yong,Deng Dexin,Zhang Zihao,Liu Kongjun,Tang Minghai,Yang Tao,Fu Suhong,Zhang Chufeng,Si Wenting,Ma Ziyan,Zhang Shunjie,Peng Bin,Xu Dingguo,Chen Lijuan^ORCID

Funder

National Natural Science Foundation of China

Sichuan University

West China Hospital, Sichuan University

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry

Reference54 articles.

1. BET inhibitors: a novel epigenetic approach;Doroshow;Ann. Oncol.,2017

2. Design, synthesis, and biological evaluation of 4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridine derivatives as novel dual-PLK1/BRD4 inhibitors;Wang;Eur. J. Med. Chem.,2020

3. Kinase and BET inhibitors together clamp inhibition of PI3K signaling and overcome resistance to therapy;Stratikopoulos;Cancer cell,2015

4. New and emerging HDAC inhibitors for cancer treatment;West;J. Clin. Invest.,2014

5. Plk1 inhibition enhances the efficacy of BET epigenetic reader blockade in castration-resistant prostate cancer;Mao;Mol. Cancer Ther.,2018

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