Delivery of ursolic acid (UA) in polymeric nanoparticles effectively promotes the apoptosis of gastric cancer cells through enhanced inhibition of cyclooxygenase 2 (COX-2)

Author:

Zhang Hao,Li Xiaolin,Ding Jing,Xu Huae,Dai Xinzheng,Hou Zhibo,Zhang Kai,Sun Kun,Sun Weihao

Funder

National Natural Science Foundation of China

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference30 articles.

1. Ursolic acid induces Bax-dependent apoptosis through the caspase-3 pathway in endometrial cancer SNG-II cells;Achiwa;Oncol. Rep.,2005

2. Ursolic acid inhibits proliferation and stimulates apoptosis in HT29 cells following activation of alkaline sphingomyelinase;Andersson;Anticancer Res.,2003

3. Triterpene acids from the leaves of Perilla frutescens and their anti-inflammatory and antitumor-promoting effects;Banno;Biosci. Biotechnol. Biochem.,2004

4. Release of hydrophobic molecules from polymer micelles into cell membranes revealed by Forster resonance energy transfer imaging;Chen;Proc. Natl. Acad. Sci. U.S.A.,2008

5. Induction of apoptosis by ursolic acid through activation of caspases and down-regulation of c-IAPs in human prostate epithelial cells;Choi;Int. J. Oncol.,2000

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