Sintilimab plus bevacizumab biosimilar IBI305 and chemotherapy for patients with EGFR-mutated non-squamous non-small-cell lung cancer who progressed on EGFR tyrosine-kinase inhibitor therapy (ORIENT-31): first interim results from a randomised, double-blind, multicentre, phase 3 trial

Author:

Lu Shun,Wu Lin,Jian Hong,Chen Ying,Wang Qiming,Fang Jian,Wang Ziping,Hu Yanping,Sun Meili,Han Liang,Miao Liyun,Ding Cuimin,Cui Jiuwei,Li Baolan,Pan Yueyin,Li Xingya,Ye Feng,Liu Anwen,Wang Ke,Cang Shundong,Zhou Hui,Sun Xing,Ferry David,Lin Yong,Wang Shuyan,Zhang Wen,Zhang Chengli

Funder

National Natural Science Foundation of China

Innovent Biologics

Publisher

Elsevier BV

Subject

Oncology

Reference30 articles.

1. Non-small cell lung cancer, version 3.2022. NCCN Clinical Practice Guidelines in Oncology;Ettinger;J Natl Compr Canc Netw,2022

2. First-SIGNAL: first-line single-agent iressa versus gemcitabine and cisplatin trial in never-smokers with adenocarcinoma of the lung;Han;J Clin Oncol,2012

3. Osimertinib or platinum-pemetrexed in EGFR T790M-positive lung cancer;Mok;N Engl J Med,2017

4. Osimertinib in untreated EGFR-mutated advanced non-small-cell lung cancer;Soria;N Engl J Med,2018

5. Randomized phase III trial of aumolertinib (HS-10296, Au) versus gefitinib (G) as first-line treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) and EGFR exon 19 del or L858R mutations (EGFRm);Lu;Proc Am Soc Clin Oncol,2021

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