Norketamine, the main metabolite of ketamine, is a non-competitive NMDA receptor antagonist in the rat cortex and spinal cord

Author:

Ebert Bjarke,Mikkelsen Søren,Thorkildsen Christian,Borgbjerg Finn Molke

Publisher

Elsevier BV

Subject

Pharmacology

Reference33 articles.

1. Pharmacology of excitatory amino acid receptors in the rat hemisected spinal cord;Birch;Eur. J. Pharmacol.,1988

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3. Interactions between glutamatergic and monoaminergic systems within the basal ganglia: Implications for schizophrenia and Parkinson's disease;Carlsson;Trends Neurosci.,1990

4. Relationship between the inhibition constant (Ki) and the concentration of inhibitor, which causes 50% inhibition (I50) of an enzymatic reaction;Cheng;Biochem. Pharmacol.,1973

5. Church, J., Lodge, D., 1990. N-methyl-d-aspartate (NMDA) antagonism is central to the actions of ketamine and other phencyclidine receptor ligands. In: E.F. Domino (Ed.), Status of Ketamine in Anesthesiology. NPP Books, Ann Arbor, pp. 501–526.

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