Author:
Cotton Hanna,Elebring Thomas,Larsson Magnus,Li Lanna,Sörensen Henrik,von Unge Sverker
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Catalysis
Reference19 articles.
1. Omeprazole: The first proton pump inhibitor
2. Substituted benzimidazoles inhibit gastric acid secretion by blocking (H+ + K+) ATPase
3. The stereochemical assignment of the enantiomers of omeprazole is described in von Unge, S.; Langer, V.; Sjölin, L. Tetrahedron: Asymmetry 1997, 8, 1967–1970.
4. The enantiomers of omeprazole have previously been isolated by resolution procedures, see: (a) Erlandsson, P.; Isaksson, R.; Lorentzon, P.; Lindberg, P. J. Chromatogr. 1990, 532, 305–319. (b) Kohl, B.; Senn-Bilfinger, J. Patent appl. DE 4035455 (Priority date: November 8, 1990). (c) Lindberg, P.; von Unge, S. Patent appl. WO 94/27988 (Priority date: May 28, 1993).
5. Sulphide 1 is a key intermediate in the production of racemic omeprazole. The synthesis of 1 is described in Carlsson, E. I.; Junggren, U. K.; Larsson, H. S.; von Wittken Sundell, G. W. Patent appl. EP 074341. (Priority date: August 13, 1981).
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