Evidence that Monastrol Is an Allosteric Inhibitor of the Mitotic Kinesin Eg5

Author:

Maliga Zoltan,Kapoor Tarun M,Mitchison Timothy J

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,General Medicine,Biochemistry

Reference31 articles.

1. The design plan of kinesin motors;Vale;Annu. Rev. Cell Dev. Biol.,1997

2. Structure and dynamics of molecular motors;Amos;Curr. Opin. Struct. Biol.,1997

3. Phosphorylation of p34cdc2 regulates spindle association of human Eg5, kinesin-related motor essential for bipolar spindle formation in vivo;Blangy;Cell,1995

4. Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen;Mayer;Science,1999

5. Finer, J.T., Bergnes, G., Feng, B., Smith, W.W., and Chabala, J.C. (May 2001). Methods and compositions utilizing quinazolinones. WIPO. WO 01/30768 A1.

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