PGC-1α Promotes Breast Cancer Metastasis and Confers Bioenergetic Flexibility against Metabolic Drugs

Author:

Andrzejewski Sylvia,Klimcakova Eva,Johnson Radia M.,Tabariès Sébastien,Annis Matthew G.,McGuirk Shawn,Northey Jason J.,Chénard Valérie,Sriram Urshila,Papadopoli David J.,Siegel Peter M.,St-Pierre Julie

Funder

Dr. John R and Clara M. Fraser Memorial Trust

Terry Fox Foundation

Québec Breast Cancer Foundation

McGill University

Canadian Institutes of Health Research

Terry Fox Research Institute

Cancer Research Society

Fonds de Recherche du Québec-Santé

Vanier Canada Graduate Scholarship

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Physiology

Reference46 articles.

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2. Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor;Aslakson;Cancer Res.,1992

3. The PGC-1α/ERRα axis represses one-carbon metabolism and promotes sensitivity to anti-folate therapy in breast cancer;Audet-Walsh;Cell Rep.,2016

4. PGC1α promotes tumor growth by inducing gene expression programs supporting lipogenesis;Bhalla;Cancer Res.,2011

5. Molecular features of biguanides required for targeting of mitochondrial respiratory complex I and activation of AMP-kinase;Bridges;BMC Biol.,2016

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