Refining the selection of patients with metastatic colorectal cancer for treatment with temozolomide using proteomic analysis of O6-methylguanine-DNA-methyltransferase

Author:

Schwartz Sarit,Szeto Chris,Tian Yuan,Cecchi Fabiola,Corallo Salvatore,Calegari Maria Alessandra,Di Bartolomeo Maria,Morano Federica,Raimondi Alessandra,Fucà GiovanniORCID,Martinetti Antonia,De Pascalis Ivana,Martini Maurizio,Belfiore Antonino,Milione Massimo,Orlandi Armando,Barault LudovicORCID,Barone Carlo,de Braud Filippo,Di Nicolantonio Federica,Benz Steve,Hembrough Todd,Pietrantonio FilippoORCID

Funder

AIRC

AIRC Special Program 5 per mille Metastases Project

Fondo per la Ricerca Locale

Università di Torino

Fondazione Piemontese per la Ricerca sul Cancro ONLUS 5 per mille 2015 Ministero della Salute

Fondazione Piemontese per la Ricerca sul Cancro ONLUS 5 per mille 2011 Ministero della Salute

RC 2017 Ministero della Salute

Publisher

Elsevier BV

Subject

Cancer Research,Oncology

Reference34 articles.

1. Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents;Pegg;Cancer Res,1990

2. Absence of the MGMT protein as well as methylation of the MGMT promoter predict the sensitivity for temozolomide;van Nifterik;Br J Cancer,2010

3. Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis;Esteller;Cancer Res,2000

4. Extent of MGMT promoter methylation correlates with outcome in glioblastomas given temozolomide and radiotherapy;Dunn;Br J Cancer,2009

5. MGMT gene silencing and benefit from temozolomide in glioblastoma;Hegi;N Engl J Med,2005

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