Tyrosine phosphorylation of DEPTOR functions as a molecular switch to activate mTOR signaling

Author:

M. Gagné Laurence,Morin Nadine,Lavoie Noémie,Bisson NicolasORCID,Lambert Jean-PhilippeORCID,Mallette Frédérick A.ORCID,Huot Marc-ÉtienneORCID

Funder

Cancer Research Society

Canadian Institutes of Health Research

Natural Sciences and Engineering Research Council of Canada

Fonds de Recherche du Québec - Santé

Fonds de recherche du Quebec Nature et technologies

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference62 articles.

1. Overexpression of mTOR and p(240-244)S6 in IDH1 wild-type human glioblastomas is predictive of low survival;Machado;J. Histochem. Cytochem.,2018

2. Activation of mTORC1/mTORC2 signaling in pediatric low-grade glioma and pilocytic astrocytoma reveals mTOR as a therapeutic target;Hutt-Cabezas;Neuro Oncol.,2013

3. Phosphorylated 4E-binding protein 1 (p-4E-BP1): A novel prognostic marker in human astrocytomas;Korkolopoulou;Histopathology,2012

4. Phenotypic variations in NF1-associated low grade astrocytomas: Possible role for increased mTOR activation in a subset;Jentoft;Int. J. Clin. Exp. Pathol.,2010

5. Activation of PI3K/mTOR pathway occurs in most adult low-grade gliomas and predicts patient survival;McBride;J. Neurooncol.,2010

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