PTP1B mediates the inhibitory effect of MFGE8 on insulin signaling through the β5 integrin

Author:

Datta Ritwik,Mukherjee Dibyanti,Podolsky Michael J.,Yang Christopher D.ORCID,Alba Diana L.,Singh Sukhmani,Arnold Thomas D.ORCID,Koliwad Suneil,Lizama Carlos O.,Atabai Kamran

Funder

American Diabetes Association

Robert Wood Johnson Foundation

National Center for Advancing Translational Sciences

University of California San Francisco

National Institutes of Health

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference41 articles.

1. alpha8beta1 integrin regulates nutrient absorption through an Mfge8-PTEN dependent mechanism;Khalifeh-Soltani;Elife,2016

2. Mfge8 promotes obesity by mediating the uptake of dietary fats and serum fatty acids;Khalifeh-Soltani;Nature medicine,2014

3. MFGE8 links absorption of dietary fatty acids with catabolism of enterocyte lipid stores through HNF4gamma-dependent transcription of CES enzymes Cell;Datta;Rep,2023

4. Mfge8 regulates enterocyte lipid storage by promoting enterocyte triglyceride hydrolase activity;Khalifeh-Soltani;JCI insight,2016

5. Autoregulation of insulin receptor signaling through MFGE8 and the alphavbeta5 integrin;Datta;Proceedings of the National Academy of Sciences of the United States of America,2021

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