A phase III, multicenter, double-blind, randomized clinical trial to evaluate the efficacy and safety of ceftolozane/tazobactam plus metronidazole versus meropenem in Chinese participants with complicated intra-abdominal infections

Author:

Sun YihongORCID,Fan Jia,Chen Gang,Chen Xiaofei,Du Xiaoling,Wang Ye,Wang Hui,Sun Fang,Johnson Matthew G.,Bensaci Mekki,Huntington Jennifer A.,Bruno Christopher J.

Funder

Merck Sharp and Dohme

Merck & Co Inc

Meso Scale Diagnostics

Publisher

Elsevier BV

Subject

Infectious Diseases,Microbiology (medical),General Medicine

Reference27 articles.

1. Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis;Cassini;Lancet Infect Dis,2019

2. Antibiotic resistance threats in the United States. Atlanta: United States Department of Health and Human Services;Centers for Disease Control and Prevention,2019

3. Efficacy and safety of tigecycline monotherapy vs. imipenem/cilastatin in Chinese patients with complicated intra-abdominal infections: a randomized controlled trial;Chen;BMC Infect Dis,2010

4. Performance standards for antimicrobial susceptibility testing,2018

5. The relationship between antimicrobial resistance and patient outcomes: mortality, length of hospital stay, and health care costs;Cosgrove;Clin Infect Dis,2006

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