Effects of short-term propofol and dexmedetomidine on pulmonary morphofunction and biological markers in experimental mild acute lung injury

Author:

Cavalcanti Vinícius,Santos Cintia Lourenço,Samary Cynthia Santos,Araújo Mariana Neves,Heil Luciana Boavista Barros,Morales Marcelo Marcos,Silva Pedro Leme,Pelosi Paolo,Fernandes Fatima Carneiro,Villela Nivaldo,Rocco Patricia Rieken Macedo

Funder

Centers of Excellence Program

Brazilian Council for Scientific and Technological Development

Carlos Chagas Filho Rio de Janeiro State Research Supporting Foundation

CAPES

FAPESP

National Institute of Science and Technology of Drugs and Medicines

European Community Seventh Framework Programme

Publisher

Elsevier BV

Subject

Pulmonary and Respiratory Medicine,Physiology,General Neuroscience

Reference43 articles.

1. Effects of sevoflurane and propofol on pulmonary shunt fraction during one-lung ventilation for thoracic surgery;Beck;Br. J. Anaesth.,2001

2. Pharmacokinetic–pharmacodynamic characterization of the cardiovascular, hypnotic, EEG and ventilatory responses to dexmedetomidine in the rat;Bol;J. Pharmacol. Exp. Ther.,1997

3. Propofol attenuates the decrease of dynamic compliance and water content in the lung by decreasing oxidative radicals released from the reperfused liver;Chan;Anesth. Analg.,2008

4. Protective effects of propofol on acute lung injury induced by oleic acid in conscious rats;Chen;Crit. Care Med.,2008

5. Nrf2 defends the lung from oxidative stress;Cho;Antioxid. Redox Signal.,2006

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