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CRISPR-Mediated Drug-Target Validation Reveals Selective Pharmacological Inhibition of the RNA Helicase, eIF4A

  • Published:2016-06 Issue:11 Volume:15 Page:2340-2347
  • ISSN:2211-1247
  • Container-title:Cell Reports
  • language:en
  • Short-container-title:Cell Reports

Author:

Chu Jennifer,Galicia-Vázquez Gabriela,Cencic Regina,Mills John R.,Katigbak Alexandra,Porco John A.,Pelletier Jerry

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology

Reference26 articles.

1. Targeting the translation machinery in cancer;Bhat;Nat. Rev. Drug Discov.,2015

2. Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model;Bordeleau;J. Clin. Invest.,2008

3. Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol;Cencic;PLoS ONE,2009

4. Translation Inhibition by Rocaglates Is Independent of eIF4E Phosphorylation Status;Chu;Mol. Cancer Ther.,2016

5. Unique translation initiation of mRNAs-containing TISU element;Elfakess;Nucleic Acids Res.,2011
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