Targeting MCL-1 triggers DNA damage and an anti-proliferative response independent from apoptosis induction

Author:

Adhikary Utsarga,Paulo Joao A.,Godes Marina,Roychoudhury Shrabasti,Prew Michelle S.,Ben-Nun Yael,Yu Ellen W.,Budhraja Amit,Opferman Joseph T.,Chowdhury Dipanjan,Gygi Steven P.,Walensky Loren D.ORCID

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology

Reference72 articles.

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3. Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands;Day;J. Biol. Chem.,2005

4. BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis;Cheng;Mol. Cell,2001

5. Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics;Letai;Cancer Cell,2002

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