The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop
Author:
Publisher
Elsevier BV
Subject
General Biochemistry, Genetics and Molecular Biology
Reference27 articles.
1. cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING;Ablasser;Nature,2013
2. Studying multiprotein complexes by multisignal sedimentation velocity analytical ultracentrifugation;Balbo;Proc. Natl. Acad. Sci. USA,2005
3. Cytoplasmic DNA innate immune pathways;Barber;Immunol. Rev.,2011
4. Structural mechanism of cytosolic DNA sensing by cGAS;Civril;Nature,2013
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