Therapeutic potential of human mesenchymal stem cells producing IL-12 in a mouse xenograft model of renal cell carcinoma

Author:

Gao Peng,Ding Qiang,Wu Zhong,Jiang Haowen,Fang Zujun

Publisher

Elsevier BV

Subject

Cancer Research,Oncology

Reference43 articles.

1. High frequency of specific CD8+ T cells in the tumor and blood is associated with efficient local IL-12 gene therapy of cancer;Fernandez;J. Immunol.,1999

2. Gene therapy with a single chain interleukin 12 fusion protein induces T cell-dependent protective immunity in a syngeneic model of murine neuroblastoma;Lode;Proc. Natl. Acad. Sci. USA.,1998

3. Contribution of natural killer cells to inhibition of angiogenesis by interleukin-12;Yao;Blood,1999

4. Intradermal delivery of IL-12 naked DNA induces systemic NK cell activation and Th1 response in vivo that is independent of endogenous IL-12 production;Watanabe;J. Immunol.,1999

5. Interleukin 12 gene therapy of a weakly immunogenic mouse mammary carcinoma results in reduction of spontaneous lung metastases via a T cell-independent mechanism;Rakhmilevich;Cancer Gene Ther.,2000

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