Absorption, tissue distribution and in vivo stability in rats of a hybrid antisense oligonucleotide following oral administration

Author:

Agrawal Sudhir,Zhang Xueshu,Lu Zhihong,Zhao Hui,Tamburin Jeffrey M.,Van Jieming,Cai Hongying,Diasio Robert B.,Habus Ivan,Jiang Zhiwei,Iyer Radhakrishnan P.,Yu Dong,Zhang Ruiwen

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference14 articles.

1. Oligonucleotide base hybridization as a modulator of genetic message readout;Zamecnik,1992

2. Pharmacokinetics, biodistribution and stability of oligodeoxynucleotide phosphorothioates in mice;Agrawal,1991

3. Disposition of the 14C-labeled phosphorothioate oligonucleotides ISIS 2105 after intravenous administration to rats;Cossum;J Pharmacol Exp Ther,1993

4. Biodistribution and metabolism of internally 3H-labeled oligonucleotides. I. Comparison of a phosphodiester and a phosphorothioate;Sands;Mol Pharmacol,1994

5. Pharmacokinetics and tissue distribution in rats of an oligodeoxynucleotide phosphorothioate (GEM 91) developed as a therapeutic agent for human immunodeficiency virus type-1;Zhang;Biochem Pharmacol,1995

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