Effect of human serum on the in vitro anti- HIV-1 activity of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio) thymine (HEPT) derivatives as related to their lipophilicity and serum protein binding

Author:

Masanori Baba,Satoshi Yuasa,Takuro Niwa,Minako Yamamoto,Shingo Yabuuchi,Hideaki Takashima,Masaru Ubasawa,Hiromichi Tanaka,Tadashi Miyasaka,Walker Richard T.,Balzarini Jan,De Clercq Erik,Shiro Shigeta

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference29 articles.

1. A novel lead for specific anti-HIV-1 agents: 1-[(2-Hydroxyethoxy)-methyl]-6-(phenylthio)thymine;Miyasaka;J Med Chem,1989

2. Highly specific inhibition of human immunodeficiency virus type 1 by a novel 6-substituted acyclouridine derivative;Baba;Biochem Biophys Res Commun,1989

3. Potent and selective inhibition of human immuno-deficiency virus type 1 (HIV-1) by 5-ethyl-6-phenyl-thiouracil derivatives through its interaction with the HIV-1 reverse transcriptase;Baba,1991

4. Highly potent and selective inhibition of human immunodeficiency virus type 1 (HIV-1) by a novel series of 6-substituted acyclouridine derivatives;Baba;Mol Pharmacol,1991

5. Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives;Pauwels;Nature,1990

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